General Cell Lines and Cell Cultures
ATCC Kluyveromyces lactis; NRRL Y-1140
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
Eurofins Discoverx PathHunter U2OS TGFBR1/TGFBR2 Dimerization Cell Line, 2 vials. (93-0889C3)
The PathHunter TGFBR1/TGFBR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. TGF-β1) induced dimerization of TGFBR1/TGFBR2 receptors. This product uses EFC technology. The cell line included overexpresses TGFBR1 target protein fused to PK alongside TGFBR2 target protein fused to EA. Upon ligand-induced dimerization of TGFBR1/TGFBR2, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx ChemiScreen CCK2 Cholecystokinin Receptor Stable Cell Line, 2 vials. (HTS083C)
The ChemiScreen CCK2 Cholecystokinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. cholecystokinin) based activation of CCKBR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCKBR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCKBR, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiBrite LH Glycoprotein Hormone Receptor Stable Cell Line, 2 vials. (HTS233L)
The ChemiBrite LH Glycoprotein Hormone Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. luteinizing hormone, hCG) based activation of LHCGR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LHCGR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of LHCGR, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC J558; Plasmacytoma; Mouse (Mus musculus)
J558 are B lymphocytes that were isolated from a mouse with plasmacytoma. It has applications in immune system disorder research and immunology.
ABclonal Technology CHRM1 Rabbit pAb
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
ATCC Primary Epidermal Keratinocytes; Normal, Human, Adult
Primary Epidermal Keratinocytes; Normal, Human, Adult (HEKa) are primary cells that provide a complete solution to propagate keratinocytes isolated from human skin. Use these cells in your research in toxicology, wound repair, skin cancer, response to UV radiation, psoriasis, eczema, viral infection, gene delivery systems, cellular differentiation, and cosmetics research/testing.
ATCC Legionella pneumophila; Philadelphia-1; genomic DNA
Genomic DNA isolated from Legionella pneumophila subsp. pneumophila strain Philadelphia-1 (ATCC 33152). This whole-genome sequenced product can be used in PCR and other molecular biology applications.
Eurofins Discoverx ChemiBrite IP1 Prostanoid Receptor Stable Cell Line, 2 vials. (HTS131L)
The ChemiBrite IP1 Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin I2) based activation of PTGIR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGIR, a naturally Gq coupled GPCR. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGIR, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Mycobacterium terrae; Strain W-45
Mycobacterium terrae strain W-45 is a whole-genome sequenced bacterial type strain. It has applications in efficacy testing, testing bactericides, and testing mycobactericides.
![ATCC Quantitative Genomic DNA from; Megasphaera elsdenii; Strain: [B159]](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502382541.PNG-250.jpg)
ATCC Quantitative Genomic DNA from; Megasphaera elsdenii; Strain: [B159]
ATCC Genuine Nucleics can be used for assay development, verification, validation, monitoring of day-to-day test variation, and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine bacterial load.
